Albendazole

Albendazole is an anti-worm drug discovered by the SmithKline’s scientists in 1972. Albendazole is used to treat certain infections caused by worms such as pork tapeworm and dog tapeworm.  It works by keeping the worm from absorbing glucose so that the worm loses energy and die.

SOLUBILITY: It is insoluble in water but it is it is slightly soluble in methanol, chloroform, ethyl acetate, and acetonitrile.
Absorption of albendazole occurs along the gastrointestinal tract and is limited by its solubility. When 0.1 M HCl was used as dissolution medium good dissolution profiles were observed.

albendazole

Molecular Formula: C12H15N3O2S

Systematic name : methyl 5-(propylthio)-2-benzimidazolecarbamate.
Molecular Weight: 265.34
Colour/Form: Colourless crystals
Melting Point: 208-210 deg C
Available Dosage Forms: Tablet
Therapeutic Class: Anthelmintic
Chemical Class: Benzimidazole

According to the Protein studies it showed that albendazole is 89-92% bound to plasma proteins. One important point to remember is Albendazole will not treat a viral infection such as the common cold or flu.

Result of Overdose:

ANIMALS-> in male and female mice toxicity and mortality were shown. If a particular dose range exceed then it may cause a severe problem.
Example: in rabbits at estimated doses between 500 and 1,250 mg/kg.
Diarrhea, vomiting, respiratory distress are some symptoms that were found in animals.

HUMANS-> during each treatment cycle blood counts should be performed on every 2 weeks. This drug basically lowers the blood cells but it as the blood counts are performed so consecutively blood checking is being done so that blood level does not get too low. As it lowers the blood cell which help in fighting body infection, which is very necessary.

Due to overdose some symptoms are found. EXAMPLE: headache, kidney failure, dizziness, sleeplessness, epigastric pain and diarrhoea.It can also cause harm to fetus and should be taken under guidance of doctors.

Due to over consumption of fatty foods the absorbstion rate of albendazole get increased. As this drug get rapidly metabolised in the liver and sometimes in intestine so it cannot be detected in plasma after 400-mg oral dose.

Before taking this medicine some tests are performed so that it won’t affect human body. Some test may include liver test because it may cause hepatotoxicity. Consumption of alchol or tobacco increase te risk of side effect and which is strictly avoided.

Other side effects reported gastrointestinal pain, abdominal pain, lethargy, even in patients with heavy worm burdens severe headaches, fever, fatigue, vertigo, dark urine, loss of hair, hives, difficulty breathing, and swelling of your face, lips, tongue, or throat.

As compared to laboratory animals the oral exposure would be less toxic to humans. The albendazole consumers revel that it is not well absorbed from human gut. Only about 1% is absorbed from human gut.

Albendazole does not produce serious toxicity if has been giving continuously 10-12 mg per day.

Albendazole is a benzimidazole carbamate and is used for the treatment of gastrointestinal infestations with tapeworms, roundworms, lungworms. It should be taken in pregnency and not even breastfeeding women should not take this medicine or a patient with hypersensitivity, liver problem.

Regular checkup is needed in this case to check the progress after treatment. And make sure that infection has removed from the root.
The acceptable daily intakes of this drug are 5 micrograms per kilogram of body weight/day. And this drug should be not be taken without food. During consumption it is important to take it with food.

If you have missed your dose then take it as soon as possible, but if it is the time to take the next dose then skip the missed dose and take the upcoming. Be regular to take medicine to cure.

If you have missed your dose then take it as soon as possible, but if it is the time to take the next dose then skip the missed dose and take the upcoming. Be regular to take medicine to cure.

Manufacturers :

LASA Laboratory Pvt Ltd leading manufacturer of Albendazole in India

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